WHAT IF I LEARN™ LABS
GENETIC ENGINEERING BY HAILEY
HOW DIRECT REPROGRAMMING CAN TRANSFORM ONE TYPE OF CELL STRAIGHT INTO ANOTHER
Teisha Rowland, PhD, Science Buddies
Learn.Genetics is a registered trademark of the University of Utah Genetic Science Learning Center
TARGET CELL TYPE
IMPORTANT TRANSCRIPTION FACTOR
OTHER CELL TYPES THAT EXPRESS IT
HIGHLY EXPRESSED IN OTHER CELL TYPES
oocytes, liver, small intestine, PNS
yes, 1 of 4
Associated with liver-specific genes. Defects can cause diabetes and liver tumors. Involved in diabetes and insulin signaling pathways.
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The encoded protein plays a part in the differentiation of photoreceptor cells, and is required for the maintenance of normal rod and cone function.
The encoded protein can bind and homodimerize DNA.
This transcription factor affects the expression of target genes that are part of cell differentiation, cell proliferation, and inflammation and immune responses.
The encoded protein controls the transcription of numerous estrogen-inducible genes that play a part in metabolism, growth, gestation, and other reproductive functions. Also, the encoded protein is expressed in numerous non-reproductive tissues.
In the cell cycle, the encoded protein acts as an S-phase checkpoint protein. Also, the encoded protein may play a part in DNA repair.
In the presence of cholesterol, the encoded protein attaches to transcription factors called sterol regulatory element binding proteins and then mediates their transport from the endoplasmic reticulum to the Golgi.
HNF4 may play a part in development of the kidney, liver and intestines. The encoded protein binds DNA as a homodimer. The encoded protein also controls the expression of a few genes, including a transcription factor called hepatocyte nuclear factor 1 alpha.
The encoded protein, a transcriptional activator, is involved in cell proliferation, and controls the expression of a few cell cycle genes, including cyclin B1 and cyclin D1.
The encoded protein contains several transactivation domains, and a zinc finger DNA-binding domain. The encoded protein also acts as a bifunctional transcription factor, either repressing or stimulating the transcription of numerous genes.
duodenum, colon, small intestine, liver
liver, appendix, testis
colon, heart, small intestine, liver, duodenum
bone marrow, gall bladder, skin, endometrium, lymph node, placenta, thyroid
bone marrow, testis, lymph node, placenta, appendix, colon, duodenum
bone marrow, brain, lung, placenta, skin, small intestine, testis, thyroid
adrenal, brain, colon, kidney, ovary, placenta, prostate, skin, spleen, testis
fat, placenta, prostate, spleen, skin, lymph node, stomach