WHAT IF I LEARN™ LABS

GENETIC ENGINEERING BY HAILEY

TARGET CELL TYPE

IMPORTANT TRANSCRIPTION FACTOR

OTHER CELL TYPES THAT EXPRESS IT

HIGHLY EXPRESSED IN OTHER CELL TYPES

KNOWN FUNCTIONS

KIDNEY

KIDNEY

KIDNEY

KIDNEY

KIDNEY

KIDNEY

KIDNEY

KIDNEY

KIDNEY

KIDNEY

HNF1

HNF4

CRX

GCNF

HNF3

PPARA

SP3

ER

TEL2

SREBP

oocytes, liver, small intestine, PNS

yes, 1 of 4

Associated with liver-specific genes. Defects can cause diabetes and liver tumors. Involved in diabetes and insulin signaling pathways.

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The encoded protein plays a part in the differentiation of photoreceptor cells, and is required for the maintenance of normal rod and cone function.

The encoded protein can bind and homodimerize DNA.

This transcription factor affects the expression of target genes that are part of cell differentiation, cell proliferation, and inflammation and immune responses.

The encoded protein controls the transcription of numerous estrogen-inducible genes that play a part in metabolism, growth, gestation, and other reproductive functions. Also, the encoded protein is expressed in numerous non-reproductive tissues.

In the cell cycle, the encoded protein acts as an S-phase checkpoint protein. Also, the encoded protein may play a part in DNA repair.

In the presence of cholesterol, the encoded protein attaches to transcription factors called sterol regulatory element binding proteins and then mediates their transport from the endoplasmic reticulum to the Golgi.

HNF4 may play a part in development of the kidney, liver and intestines. The encoded protein binds DNA as a homodimer. The encoded protein also controls the expression of a few genes, including a transcription factor called hepatocyte nuclear factor 1 alpha.

The encoded protein, a transcriptional activator, is involved in cell proliferation, and controls the expression of a few cell cycle genes, including cyclin B1 and cyclin D1.

The encoded protein contains several transactivation domains, and a zinc finger DNA-binding domain. The encoded protein also acts as a bifunctional transcription factor, either repressing or stimulating the transcription of numerous genes.

duodenum, colon, small intestine, liver

liver, appendix, testis

colon, heart, small intestine, liver, duodenum

endometrium, prostate

bone marrow, gall bladder, skin, endometrium, lymph node, placenta, thyroid

bone marrow, testis, lymph node, placenta, appendix, colon, duodenum

bone marrow, brain, lung, placenta, skin, small intestine, testis, thyroid

adrenal, brain, colon, kidney, ovary, placenta, prostate, skin, spleen, testis

yes

yes

yes

yes

no